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. 2012 Sep 25;7(9):e46196. doi: 10.1371/journal.pone.0046196

Figure 2. Evaluation of neuronal density on NeuN stained sections after icv- streptozotocin.

Figure 2

A. Histological sections showing the septum (S), striatum (Cpu) and lateral ventricles (LV) in the control, 1 mg/kg and 3 mg/kg streptozotocin-treated animals, one week and three months post injection. Dilation of ventricles and septal alterations are visible in the 3 mg/kg-treated group (arrows). B. Septal neurons density started to decrease one week post injection in the 3 mg/kg group but not in the 1 mg/kg animals. This septal neuronal alteration worsened with time and was highlighted in 1 mg/kg and 3 mg/kg streptozotocin-treated animals three months following the administration of the toxic. C. No modifications of the striatal NeuN labeling density were highlighted one week or three months post injection in control group and in both streptozotocin-treated group. Values are mean±SEM. *: p<0.05; ***: p<0.005. Scale bars = 2 mm.