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. 2012 Sep 25;7(9):e45357. doi: 10.1371/journal.pone.0045357

Figure 1. LINE-1 methylation analysis by bisulfite pyrosequencing in different CRC subsets.

Figure 1

Bisulfite pyrosequencing of LINE-1 in colorectal tissues; Normal mucosa (n = 32), early-onset CRC from Argentina (n = 116), early-onset CRC from Spain (n = 70), older onset CRC with microsatellite stability (MSS; n = 89), older onset CRC with microsatellite instability (MSI) associated with MLH1 promoter hypermethylation (n = 46) and Lynch syndrome CRCs (n = 20).The black horizontal bar indicates the mean methylation level.