Figure 6. La³⁺ and Gd³⁺ suppress store-operated Ca²⁺ entry evoked by CPA in endothelial progenitor cells.

La³⁺ (10 µM) and Gd³⁺ inhibit CPA-induced SOCE in both N-EPCs (A) and RCC-EPCs (C). CPA was applied at 10 µM and the cells were pre-incubated for 20 min with either trivalent cation before store emptying. The traces are representative of the experiments conducted on EPCs from at least three different donors for each condition. Mean±SE of the amplitude of CPA-induced Ca²⁺ release and CPA-induced SOCE in the absence and presence of each trivalent cation in both N-EPCs (C) and RCC-EPCs (D). The asterisk indicates p<0.05.