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. 2012 Sep 25;7(9):e44388. doi: 10.1371/journal.pone.0044388

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© 2012 Tigerholm et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Spike activity for the functionally corrected model of the increased Na current pathology model. (B) Spike activity for the functionally corrected model of the decreased K_A current pathology model. To functionally correct the two pathologies the steady-state activation and inactivation curves of K_A were shifted −3.2 mV (increased Na current pathology) and −11 mV (decreased K_A current pathology). (C) Shift regions for the K_A steady-state curves where the pathologies were functionally corrected (generated zero spikes for synchronicity level 0 ms and 15 spikes for synchronicity level 2 ms).