Table 1. The therapeutic intervals of the concentration needed to functionally correct two pathological models.
| Increased Na current pathology | Decreased KA current pathology | |||
| Shift (mV) | Concentrations (μM) | Shift (mV) | Concentrations (μM) | |
| Nainact. | 4.3–7.2 | 1.7–2.8 | 14.0–16.3 | - |
| KA,act. | 0.9–1.8 | 8.2–18 (0.82–1.8*) | 4.8–5.6 | 79–110 (7.9–11*) |
| KDR,act. | - | - | - | - |
| ΔVm | 0.6–1.5 | <3.9 | 3.6–4.5 | ∼10 |
| Naact. + Nainact. | - | - | - | - |
| KA,act. + KA,inact. | 1.5–3.5 | 15–45 (1.5–4.5*) | 8.6–11.1 | >680 (>68*) |
| Nainact. + KA,act. +KA,inact. +ΔVm | Varies | <1.5 (<1.1*) | Varies | <4.8 (<3.5*) |
*
denotes CA1 affinity.