Table 2. Univariate Cox Analysis of Predictors of Early Mortality.
Variable | Deaths(total = 14)n (%) | Survivors(total = 213)n (%) | Hazard ratio(95% CI) | p |
White race | 7 (50) | 100 (47) | 1.13 (0.39–3.22) | 0.82 |
Age >40 | 6 (43) | 68 (32) | 1.52 (0.53–4.35) | 0.43 |
Male sex | 12 (86) | 150 (70) | 2.53 (0.56–11.5) | 0.23 |
Men who have sex with men | 4 (29) | 62 (29) | 1.07 (0.33–3.48) | 0.90 |
Alcohol abuse | 3 (22) | 51 (24) | 0.97 (0.26–3.53) | 0.96 |
Intravenous drug use | 1 (7) | 11 (5) | 1.31 (0.18–9.53) | 0.79 |
Other illicit drugs use | 3 (22) | 61 (29) | 0.73 (0.20–2.62) | 0.63 |
School education >8 years | 6 (43) | 82 (39) | 1.19 (0.41–3.40) | 0.75 |
Monthly income ≤ U$500.00 | 9 (64) | 152 (71) | 0.87 (0.27–2.78) | 0.82 |
Time since HIV diagnosis (for each month)a | 3.5 | 17.0 | 1.00 (0.99–1.01) | 0.97 |
HAART naïve | 8 (57) | 129 (61) | 0.99 (0.30–3.26) | 0.99 |
TB as criteria for AIDS diagnosis | 8 (57) | 89 (42) | 2.26 (0.66–7.74) | 0.20 |
Disseminated TB | 9 (64) | 67 (32) | 4.02 (1.37–11.8) | 0.01 |
Weight loss >10% | 7 (50) | 146 (69) | 0.58 (0.18–1.88) | 0.36 |
Positive smear | 11 (79) | 135 (63) | 3.13 (0.67–14.7) | 0.15 |
Hemoglobin ≥10g% | 3 (21) | 110 (52) | 0.23 (0.06–0.81) | 0.02 |
Serum albumin ≥3g%b | 3 (21) | 92 (51) | 0.26 (0.07–0.96) | 0.04 |
TB symptoms for >120 days | 6 (43) | 66 (31) | 1.65 (0.57–4.8) | 0.36 |
CD4 cell count >100 cells/mm3c | 3 (21) | 126 (56) | 0.27 (0.08–0.96) | 0.04 |
Unknown CD4 cell count | 7 (50) | 25 (12) | 6.80 (2.33–20.0) | <0.001 |
Viral load (for each log/mL)d | 5.22 | 4.89 | 9.40 (1.29–68.7) | 0.03 |
Resistance to one anti-TB drug | 0 | 23 (11) | Undefined | 0.07 |
Multi-drug resistance | 0 | 8 (4) | Undefined | 0.30 |
Susceptible TB treated with rifampin | 11 (79) | 174 (82) | 0.85 (0.23–3.07) | 0.80 |
IRIS | 2 (14) | 12 (6) | 2.73 (0.61–12.0) | 0.19 |
HAARTe | 7 (50) | 186 (87) | 0.23 (0.07–0.76) | 0.01 |
TB = tuberculosis; CI = confidence interval; HAART = highly active anti-retroviral therapy; IRIS = immune reconstitution inflammatory syndrome;
median;
missing data for 37 (16%) patients;
missing data for 32 (14%) patients;
missing data for 50 (22%) patients;
time-dependent variable.