Skip to main content
. 2012 Sep 25;7(9):e45704. doi: 10.1371/journal.pone.0045704

Table 2. Univariate Cox Analysis of Predictors of Early Mortality.

Variable Deaths(total = 14)n (%) Survivors(total = 213)n (%) Hazard ratio(95% CI) p
White race 7 (50) 100 (47) 1.13 (0.39–3.22) 0.82
Age >40 6 (43) 68 (32) 1.52 (0.53–4.35) 0.43
Male sex 12 (86) 150 (70) 2.53 (0.56–11.5) 0.23
Men who have sex with men 4 (29) 62 (29) 1.07 (0.33–3.48) 0.90
Alcohol abuse 3 (22) 51 (24) 0.97 (0.26–3.53) 0.96
Intravenous drug use 1 (7) 11 (5) 1.31 (0.18–9.53) 0.79
Other illicit drugs use 3 (22) 61 (29) 0.73 (0.20–2.62) 0.63
School education >8 years 6 (43) 82 (39) 1.19 (0.41–3.40) 0.75
Monthly income ≤ U$500.00 9 (64) 152 (71) 0.87 (0.27–2.78) 0.82
Time since HIV diagnosis (for each month)a 3.5 17.0 1.00 (0.99–1.01) 0.97
HAART naïve 8 (57) 129 (61) 0.99 (0.30–3.26) 0.99
TB as criteria for AIDS diagnosis 8 (57) 89 (42) 2.26 (0.66–7.74) 0.20
Disseminated TB 9 (64) 67 (32) 4.02 (1.37–11.8) 0.01
Weight loss >10% 7 (50) 146 (69) 0.58 (0.18–1.88) 0.36
Positive smear 11 (79) 135 (63) 3.13 (0.67–14.7) 0.15
Hemoglobin ≥10g% 3 (21) 110 (52) 0.23 (0.06–0.81) 0.02
Serum albumin ≥3g%b 3 (21) 92 (51) 0.26 (0.07–0.96) 0.04
TB symptoms for >120 days 6 (43) 66 (31) 1.65 (0.57–4.8) 0.36
CD4 cell count >100 cells/mm3c 3 (21) 126 (56) 0.27 (0.08–0.96) 0.04
Unknown CD4 cell count 7 (50) 25 (12) 6.80 (2.33–20.0) <0.001
Viral load (for each log/mL)d 5.22 4.89 9.40 (1.29–68.7) 0.03
Resistance to one anti-TB drug 0 23 (11) Undefined 0.07
Multi-drug resistance 0 8 (4) Undefined 0.30
Susceptible TB treated with rifampin 11 (79) 174 (82) 0.85 (0.23–3.07) 0.80
IRIS 2 (14) 12 (6) 2.73 (0.61–12.0) 0.19
HAARTe 7 (50) 186 (87) 0.23 (0.07–0.76) 0.01

TB = tuberculosis; CI = confidence interval; HAART = highly active anti-retroviral therapy; IRIS = immune reconstitution inflammatory syndrome;

a

median;

b

missing data for 37 (16%) patients;

c

missing data for 32 (14%) patients;

d

missing data for 50 (22%) patients;

e

time-dependent variable.