Table 1. Characterization of human primary tumor, chest wall recurrence and bone marrow metastasis.
Marker | Primary Foci #1-5 | Primary Foci #6 | Chest Wall Recurrence | Bone Marrow Metastasis |
ER | (−) | (−) | nt | nt |
PR | (−) | (−) | nt | nt |
HER2/neu | Not amplified | Not amplified | nt | nt |
CK5 | (+) | (++) | (++) | (+++) |
CK14 | (+) | (+) | (+) | (+) |
CK8/18 | (+) | (++) | (+) | (+++) |
E-cadherin | ||||
membrane | (++) | (+) | (+) | (+++) |
cytoplasmic | (++) | (++) | (+) | (++) |
Vimentin | (+) | (+++) | (+++) | (+) |
Qualitative evaluation based on in situ hybridization for Her2, and based on immunohistochemistry for all other markers.