Table 2. Summary of DKAT marker expression (MEGM/SCGM).
DKAT line | ||
Marker | MEGM media | SCGM media |
ER | (−) | (−) |
PR | (−) | (−) |
HER2 | Not amplified | Not amplified |
EGFR | (+) | (+) |
CK5 | (++) | (−) |
CK14 | (−) | (−) |
CK17 | (++) | (+/−) |
CK8 | (++) | (+/−) |
CK18 | (++) | (+/−) |
E-cadherin | ||
membrane | (+) | (−) |
cytoplasmic | (+) | (+) |
vimentin | (+/−) | (+++) |
p63 | (+) | (−) |
snail-1 | (++) | (++) |
snail-2/slug | (+) | (+) |
claudin-1 | (+) | (−) |
claudin-4 | (+) | (−) |
occludin | (+) | (−) |
Akt | (+) | (+) |
pAkt-Ser473 | (+++) | (++) |
PTEN | (−) | (+) |
p53 | mutant | mutant |
PI3K | wt | wt |
Qualitative evaluation based on immunofluorescence or western blot of DKAT cells grown in MEGM or following 14 days in SCGM media.