Table 1.
Demographic and clinical characteristics associated with Transmitted HIV Drug Resistance among antiretroviral naïve acutely and chronically HIV-infected patients, UCHCC 1999–2010
| TDR N (%) |
No TDR N (%) |
PR | 95% CI | P | |
|---|---|---|---|---|---|
| Total | 67 (9.3) | 653 (90.7) | |||
| Acute HIV Infection | |||||
| No | 58 (8.6) | 619 (91.4) | Ref | ||
| Yes | 9 (20.9) | 34 (79.1) | 2.44 | 1.30, 4.59 | 0.006 |
| Sex | |||||
| Male | 52 (10.1) | 462 (89.9) | Ref | ||
| Female | 15 (7.3) | 191 (92.7) | 0.72 | 0.41, 1.25 | 0.24 |
| Race | |||||
| Black | 39 (9.4) | 374 (90.6) | Ref | ||
| White | 19 (9.6) | 180 (90.5) | 1.01 | 0.60, 1.70 | 0.97 |
| Hispanic | 3 (4.4) | 65 (95.6) | 0.47 | 0.15, 1.47 | 0.19 |
| Other | 6 (15.0) | 34 (85.0) | 1.59 | 0.72, 3.52 | 0.25 |
| MSM | |||||
| No | 29 (7.1) | 382 (92.9) | Ref | ||
| Yes | 38 (12.3) | 271 (87.7) | 1.74 | 1.10, 2.76 | 0.02 |
| IDU | |||||
| No | 64 (9.7) | 595 (90.3) | Ref | ||
| Yes | 3 (4.9) | 58 (95.1) | 0.51 | 0.16, 1.56 | 0.24 |
| Year of Genotype | |||||
| Median (IQR) | 2006 (2003–2008) | 2005 (2001–2007) | 1.09† | 1.02, 1.18† | 0.02 |
|
Months Between HIV Diagnosis and Genotype |
|||||
| Median (IQR) | 2.4 (0.8–15.4) | 1.9 (0.7–8.5) | 1.00 | 0.99, 1.01 | 0.95 |
| Age at Diagnosis | |||||
| Mean (SD) | 34.1 (11.1) | 36.3 (10.8) | 0.84† | 0.67, 1.04† | 0.11 |
| CD4 cell Count (cells/mm3) | |||||
| Median (IQR) | 255 (60–446) | 290 (98–539) | 1.07† | 1.00, 1.14† | 0.06 |
| HIV RNA level (log10 copies/mL) | |||||
| Median (IQR) | 4.8 (4.2–5.4) | 4.7 (4.2–5.3) | 0.99† | 0.75, 1.29† | 0.92 |
†
Year of genotype estimates per 1 calendar year increase; Age estimates per 10 year increase in age; CD4 cell count estimates per 100 cells/ml increase; HIV RNA level estimates per 1 log10 copies/mL increase
UCHCC= University of North Carolina Center for AIDS Research HIV Clinical Cohort; TDR= Transmitted Drug Resistance; MSM= Men who have sex with men; IDU= Injection drug user