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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: J Membr Biol. 2012 Jul 24;245(8):465–476. doi: 10.1007/s00232-012-9464-0

Figure 1.

Figure 1

Schematic representation of proposed steps that lead to GJ internalization (steps 1–3), cytoplasmic AGJ vesicle formation and fragmentation (steps 4, 5), and AGJ vesicle degradation by phago-/lysosomal (steps 6–10) and endo-/lysosomal pathways (steps 11–15) based on the previous work by others and us (see text for details). Note the proposed non-junctional membrane domains missing the green GJ label (shown in steps 4, 5, 11, 12), and the increased phosphorylation and ubiquitination on AGJ vesicles that fuse with endosomes (steps 11, 12 versus 6, 7). (Adapted from Falk et al. 2009 and Fong et al. 2012.)