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Injury Model
| Phase 1 Injury and hemorrhage (50 min) | Phase 2 Prehospital-ambulance (30 min) | Phase 3 Definitive-hospital (30 min) | Phase 4 Test outcome (6 h) |
|---|---|---|---|
| •Ventilate (air) •Mild TBI •Withdraw blood to MAP 40 mm Hg |
• Ventilate (air) • Initial resuscitation-saline MAP ≥ 50 mm Hg |
• Give drug • Ventilate with 100% oxygen • Reinfuse blood • Saline to MAP ≥ 60 mm Hg |
• 0-6 h Monitor cerebral hemodynamics • 6 h Determine SO and NO levels |
