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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Gastroenterology. 2012 Jun 13;143(4):1048–1060.e4. doi: 10.1053/j.gastro.2012.06.005

Figure 2. Early expansion and long-term persistence of HCV-specific CD8 T cells during HCV-challenge of vaccinees.

Figure 2

Serum HCV RNA titers (filled diamonds) and ALT levels (open squares) of four vaccinated chimpanzees have previously been reported 12 and are shown for reference purposes. Error bars represent the standard error of the mean from 3 experiments. The HCV protein and first amino acid position of the epitope presented by the tetramer is indicated in each panel. Ad3X, 3 consecutive vaccinations with a replication-defective recombinant adenovirus encoding HCV NS3-5B; DNA3X, 3 consecutive boosts with recombinant DNA plasmid encoding HCV NS3-5B.