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Proposed model of LH/hCG-mediated activation of mTORC1 signal regulating androgen synthesis in T-I cells. The results of the present study support the schematic model by which LH/hCG activates mTORC1. As a result, mTORC1 enhances downstream targets, S6K1 and eIF4E as well as CREB and steroidogenic enzyme expression. Inhibition of mTORC1 blocks LH/hCG-stimulated androgen production by reducing the expression of steroidogenic enzymes.
