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Proteins required for replisome assembly in eukaryotes.
| S. cerevisiae | Homo sapiens |
|---|---|
| PREREPLICATION COMPLEX | |
| ORC(1–6) | ORC(1–6) |
| Cdc6 | Cdc6 |
| Cdt1 | Cdt1 |
| Mcm(2–7) | Mcm(2–7) |
| HBO1 | |
| PREINITIATION COMPLEX | |
| Mcm(2–7) | Mcm(2–7) |
| sCdc45 | Cdc45 |
| Sld3 | Treslin |
| Sld2 | RecQ4 |
| Dpb11 | TopBP1 |
| GINS | GINS |
| Pol-ε | Pol-ε |
| Mcm10 | Mcm10 |
| RPA | RPA |
| REPLISOME | |
| Mcm(2–7) | Mcm(2–7) |
| Cdc45 | Cdc45 |
| GINS | GINS |
| Pol-ε | Pol-ε |
| Mcm10 | Mcm10 |
| RPA | RPA |
| Pol-α:primase | Pol-α:primase |
| Pol-δ | Pol-δ |
