Table 2.

Effect of CDK deletions on mouse development.

Deletion	Phenotype	Reference
Cdk1	Embryonic lethality during first cell divisions	Santamaria et al. (2007)
Cdk2	Reduced body size, impaired neural progenitor cell proliferation, infertility in males and females	Berthet et al. (2003), Ortega et al. (2003)
Cdk3	Viable and fertile	Ye et al. (2001)
Cdk4	Reduced body size, insulin deficient diabetes, infertility in males and females	Rane et al. (1999), Tsutsui et al. (1999)
Cdk5	Death at birth, severe neurological defects	Ohshima et al. (1996)
Cdk6	Fertile hypoplasia of thymus and spleen, defects in hematopoiesis	Malumbres et al. (2004)
Cdk4 + Cdk6	Lethality between embryonic day E14.5 and birth. Defective hematopoiesis, MEFs are viable	Malumbres et al. (2004)
Cdk2 + Cdk4	Lethality between E14.5 and E16.5, cardiac and hematopoietic abnormalities	Berthet et al. (2006)
Cdk2 + Cdk6	Infertility in males and females, defective hematopoiesis	Malumbres et al. (2004)
Cdk2 + Cdk4 + Cdk6	Lethality by E13.5 due to hematopoietic defects. MEFs proliferate slowly, but become immortal	Santamaria et al. (2007)