Table 3.

Effect of cyclin deletions on mouse development.

Deletion	Phenotype	Reference
CcnA1	Viable, infertile males	Liu et al. (1998)
CcnA2	Death by E5.5	Murphy et al. (1997), Kalaszczynska et al. (2009)
CcnB1	Death by E10.5	Brandeis et al. (1998)
CcnB2	Viable and fertile	Brandeis et al. (1998), Draviam et al. (2001)
CcnD1 or D2 or D3	Viable and fertile	Ciemerych et al. (2002)
CcnD1 + D2 + D3	Death by E16.5, proliferative defects in hematopoietic cells and cardiac myocytes, viable MEFs	Kozar et al. (2004)
CcnE1 or E2 CcnE1 + E2	Viable and fertile Late embryonic death, rescued using wild-type placenta, no TG endoreplication, viable MEFs	Geng et al. (2003), Parisi et al. (2003)