Table 12.

Effect of piperine on plasma concentration of ampicillin in rabbits [95].

Time (h)	Ampicillin (μg/mL)	Ampicillin + piperine (μg/mL)
0.0	0	0
0.5	30.584 ± 0.38	35.481 ± 0.26
1.0	44.668 ± 0.32	251.188 ± 0.27
1.5	31.672 ± 0.49	188.364 ± 0.31
2.0	26.607 ± 0.37	84.139 ± 0.31
2.5	18.836 ± 0.38	66.834 ± 0.26
3.0	17.782 ± 0.32	35.481 ± 0.27
3.5	12.589 ± 0.31	33.496 ± 0.26
4.0	12.589 ± 0.32	26.607 ± 0.27
4.5	9.441 ± 0.26	26.607 ± 0.27

n = 6, mean ± SD, P < 0.05.