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. 2012 Sep 17;2012:637953. doi: 10.1100/2012/637953

Table 14.

Pharmacokinetic parameters of ampicillin, norfloxacin, and in combination with piperine after oral treatment in rabbit [95].

Treatment t max⁡ (h) C max⁡ (μg/mL) t 1/2 (h) AUC (μg·h/mL)
Ampicillin (150mg/kg) 1 ± 0.31 44.6 ± 0.27 1.3 ± 0.46 103.7 ± 0.52
Ampicillin (150mg/kg)
+ piperine (20mg/kg)
1.1 ± 0.3 251.2 ± 0.28 1.9 ± 0.57 350.49 ± 0.47
Norfloxacin (150mg/kg) 3.1 ± 0.32 11 ± 0.26 1.75 ± 0.38 63.98 ± 0.51
Norfloxacin (150mg/kg) + piperine (20mg/kg) 3.2 ± 0.31 16.1 ± 0.27 2.97 ± 0.38 111.69 ± 0.54

n = 6, mean ± SD, P < 0.05.