Table 15.

Comparative pharmacokinetic parameters after oral administration of metronidazole and in combination with piperine in rabbits [98].

Pharmacokinetic	Metronidazole	Metronidazole + piperine
parameters
C max⁡ (ng/mL)	3,805.89 ± 233.8	6,007.07 ± 348.8
AUC0–24 (ng·h/mL)	45,073.75 ± 713.7	84,980.98 ± 345.6
t max⁡ (h)	1.66 ± 0.57	1.66 ± 0.57
K el (mL/h)	0.06 ± 0.02	0.04 ± 0.02
t 1/2 (h)	1.48 ± 1.23	12.24 ± 1.04
V d (L)	2.69 ± 0.23	1.48 ± 0.65