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Comparison of pharmacokinetic parameters of atenolol- and atenolol + piperine-treated male New Zealand white rats after single oral administration (100 mg/kg) [103].
| Pharmacokinetic | Atenolol | Atenolol + piperine |
|---|---|---|
| parameters | ||
| C max (pg/mL) | 22,453 ± 233 | 37,860 ± 348 |
| AUC0–24 (pg·h/mL) | 1,07,189 ± 1615 | 1,52,011 ± 2354 |
| t max (h) | 2.0 ± 0.0 | 2.0 ± 0.0 |
| K el (mL/h) | 0.27 ± 0.005 | 0.25 ± 0.010 |
| t 1/2 (h) | 6.27 ± 0.057 | 6.72 ± 0.100 |
| V d (L) | 4.54 ± 0.786 | 2.88 ± 0.305 |
n = 3, mean ± SE.
