Table 21.
Enhancement of antibiotic activity by niaziridin* in combination with antibiotics against different organisms [145, 146].
| Organisms | Antibiotics | Concentration (μg/mL) | Fold enhancement of activity |
|---|---|---|---|
| E. coli (CA8000) | Rifampicin | 20.0 | 38.8 |
| Rifampicin | 30.0 | 12.6 | |
| Ampicillin | 6.0 | 5.3 | |
| Tetracycline | 1.0 | 2.3 | |
| Tetracycline | 2.0 | 5.2 | |
| Nalidixic acid | 6.0 | 50.0 | |
| B. subtilis (MTCC121) | Rifampicin | 0.05 | 19.4 |
| Ampicillin | 0.01 | 5.1 | |
| Tetracycline | 1.0 | 3.5 | |
| Nalidixic acid | 2.0 | 7.0 | |
| M. smegmatis (MC2 155) | Rifampicin | 0.05 | 1.9 |
| Ampicillin | 0.01 | 4.7 | |
| Tetracycline | 1.0 | 4.0 | |
| Nalidixic acid | 2.0 | 1.2 |
*Dose: E. coli = 0.1 μg/kg; B. subtilis and M. smegmatis = 1.0 μg/kg.