Table 28.

Pharmacokinetic parameters of paeoniflorin (150 mg/kg) and in combination with sinomenine (90 mg/kg) after oral administration in rats [201].

Parameters	Paeoniflorin	Sinomenine + paeoniflorin
AUC0–∞ (μg·h/mL)	124.62 ± 36.91	1540.43 ± 548.96**
C max⁡ (μg/mL)	1.26 ± 0.23	6.03 ± 2.45*
t max⁡ (min)	45.00 ± 5.00	77.30 ± 17.50*
t 1/2 (min)	19.58 ± 9.01	53.78 ± 22.17***
ClB (mL/kg/min)	1301.83 ± 429.03	110.44 ± 45.61*
V d (mL/kg)	102044.14 ± 46608.43	16064.25 ± 17189.33***
MRT (min)	133.12 ± 38.63	224.07 ± 26.62*

n = 6, mean ± SD; *P < 0.01, **P < 0.001, ***P < 0.05.