Table 29.

Pharmacokinetic parameters of paclitaxel (40 mg/kg) and in combination with pretreated quercetin rats after oral administration [218].

Parameters	Paclitaxel control	Quercetin pretreatment
		2 mg/kg	10 mg/kg	20 mg/kg	3 days, 10 mg/kg	3 days, 20 mg/kg
AUC (ng·h/mL)	1605 ± 409	2835 ± 721*	4205 ± 1103**	4978 ± 1211**	5123 ± 1263**	5301 ± 1328**
C max⁡ (ng/mL)	104 ± 27	161 ± 31*	248 ± 63**	279 ± 71**	288 ± 74**	299 ± 76**
t max⁡ (h)	2.0 ± 0.6	1.6 ± 0.5	1.5 ± 0.4	1.5 ± 0.5	1.5 ± 0.4	1.5 ± 0.4
t 1/2 (h)	9.9 ± 2.5	13.9 ± 3.5	16.6 ± 4.4*	17.5 ± 4.5*	17.6 ± 4.6*	17.9 ± 4.7*
MRT (h)	15 ± 3.8	22 ± 5.6	25 ± 6.4*	26 ± 6.5*	26 ± 6.4*	26 ± 6.5*
AB (%)	2.0	3.5*	5.3**	6.2**	6.4**	6.6**
RB (%)	100	176	261	309	318	329

n = 8, mean ± SD; *P < 0.05; **P < 0.01, significant difference compared to control.