Table 31.

Pharmacokinetic parameters of etoposide (9 mg/kg) and in combination with quercetin after oral administration in rats [220].

Parameters	Etoposide control	Quercetin + etoposide
		1 mg/kg	5 mg/kg	15 mg/kg
AUC (ng·h/mL)	1226 ± 154	1419 ± 222	1753 ± 315*	1878 ± 364**
C max⁡ (ng/mL)	484 ± 74.7	455 ± 80.5	586 ± 89.5*	673 ± 93.3*
ClB (mL/kg/h)	8265 ± 1566	7178 ± 1391	5980 ± 1292*	5481 ± 1167*
t max⁡ (h)	0.500 ± 0.158	0.667 ± 0.129	0.693 ± 0.154	0.708 ± 0.188
K el (/h)	0.255 ± 0.031	0.230 ± 0.027	0.225 ± 0.025	0.221 ± 0.018
t 1/2 (h)	2.75 ± 0.32	3.05 ± 0.37	3.11 ± 0.39	3.16 ± 0.41
AB (%)	8.87 ± 1.33	10.3 ± 1.55	12.7 ± 1.96*	13.6 ± 2.24**
RB (%)	100	116	143	153

n = 6, mean ± SD; *P < 0.05, **P < 0.01 compared to control.