Table 32.
Pharmacokinetic parameters of doxorubicin (50 mg/kg) and in the presence or absence (control) of quercetin (0.6, 3, and 15 mg/kg) after oral administration [215].
| Parameters | Doxorubicin (control) | Doxorubicin + quercetin | ||
|---|---|---|---|---|
| 0.6 mg/kg | 3 mg/kg | 15 mg/kg | ||
| AUC0–∞ (ng·h/mL) | 186 ± 44.6 | 244 ± 63.2* | 344 ± 98.6** | 439 ± 107.3** |
| C max (ng/mL) | 20.2 ± 5.13 | 27.3 ± 6.42* | 38.0 ± 9.28* | 45.6 ± 11.16** |
| t max (h) | 0.25 | 0.25 | 0.25 | 0.25 |
| V ss (L/min) | 6.54 ± 1.45 | 5.06 ± 1.13 | 2.88 ± 0.64* | 2.23 ± 0.52* |
| t 1/2 (h) | 13.5 ± 3.32 | 13.7 ± 3.41 | 13.8 ± 3.51 | 13.9 ± 3.82 |
| AB (%) | 3.04 ± 0.74 | 4.01 ± 0.94* | 5.58 ± 1.32** | 7.12 ± 1.71** |
| RB (%) | 100 | 132 | 185 | 236 |
n = 7, mean ± SD; *P < 0.05, **P < 0.01 significant difference compared to control.