Table 33.

Pharmacokinetic parameters of verapamil (9 mg/kg) and in combination with naringin pretreated rabbits after oral administration [222].

Parameters	Verapamil control	Naringin pretreatment
		1.5 mg/kg	7.5 mg/kg	15 mg/kg
AUC (ng·h/mL)	291 ± 75.7	370 ± 96.1*	445 ± 1025**	494 ± 142**
C max (ng/mL)	55.3 ± 14.4	66.5 ± 17.3	86.9 ± 53.3**	92.6 ± 54.5**
t max⁡ (h)	0.25 ± 0.07	0.25 ± 0.08	0.25 ± 0.06	0.25 ± 0.08
K a(/h)	3.8 ± 0.99	5.1 ± 1.30	6.1 ± 1.59*	6.8 ± 1.72*
t 1/2 (h)	12.0 ± 3.12	13.4 ± 3.46	13.6 ± 3.51	13.9 ± 3.61
AB (%)	8.8 ± 2.3	11.2 ± 2.8*	13.5 ± 3.2**	15.0 ± 3.4**
RB (%)	100	126	153	169

n = 6, mean ± SD; *P < 0.05, **P < 0.01, significant difference compared to control.