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Comparative pharmacokinetic parameters after oral supplementation of curcumin and curcumin + piperine in human volunteers [79].
| Parameters | Curcumin | Curcumin (2 g/kg) + piperine |
|---|---|---|
| (2 g/kg) | (20 mg/kg) | |
| C max (μg/mL) | 1.35 ± 0.23 | 1.80 ± 0.16 |
| t max (h) | 0.83 ± 0.05 | 1.29 ± 0.23 |
| t 1/2 (h) | 1.70 ± 0.58 | 1.05 ± 0.18 |
| AUC (μg·h/mL) | 2.36 ± 0.28 | 3.64 ± 0.31 |
| ClB (L/h) | 713 ± 12 | 495.90 ± 193.90 |
