Table 1.
Protein phosphorylation of adult CNS stem/progenitor cells, EPCs, and neoplastic ECs.
|
pPeptides (pPeptides/total peptides) |
pSites | Multi-pPeptides | |||||
|---|---|---|---|---|---|---|---|
| (pSite/total pSites) | (single or multi-pSite peptides/total pPeptides) | ||||||
| Serine | Threonine | Tyrosine | 1p | 2p | >2p | ||
| Neurospheres | 495 (91.2%) | 443 (84.2%) | 71 (13.5%) | 12 (2.3%) | 401 (81.0%) | 74 (14.9%) | 20 (4.0%) |
| EPCs | 250 ± 5 (59.7%) | 194 ± 8 (87.4%) | 20 ± 3 (9.0%) | 8 ± 0 (3.6%) | 228 ± 6 (91.0%) | 19 ± 0 (7.4%) | 4 ± 0 (1.6%) |
| Neoplastic ECs | 980 (97.8%) | 896 (88.1%) | 103 (10.1%) | 18 (1.8%) | 675 (68.9%) | 256 (26.1%) | 49 (5.0%) |
pPeptides, phosphopeptides; pSites, phosphorylation sites; multi-pPeptides, multi-phosphorylated peptides; 1p, single-phosphorylated site; 2p, two phosphorylated sites. Data are mean ± standard deviation.