Fig. 4.
Antibody-assisted plasma accumulation of brain Aβ reveals faster brain-to-blood appearance rate in PDAPP mice overexpressing LDLR. (A) Representative plasma accumulation experiment illustrating kinetics of brain-derived Aβ appearance in plasma collected by serial retro-orbital bleeds following HJ5.1 treatment. Appearance rates were calculated from the slopes of individual linear regressions, e.g., for A, 82.1 pg⋅mL−1⋅min−1. (B) Mean rate of Aβ appearance in PDAPP+/− mice expressing normal levels of LDLR (PD-NTG) or PDAPP+/− mice overexpressing LDLR (PD-TG) (n = 6–7 per group; 3.5–4.5 mo old). Difference between groups was analyzed using two-tailed Student’s t test. *P < 0.05. Values in B represent mean ± SEM.