Fig. 1.

S. aureus SarA/MgrA family protein. (A) Model of gene regulation by the oxidation-sensing SarA/MgrA/SarZ. The N-terminal Cys residue, highly conserved in SarA/MgrA/SarZ, is subject to oxidation by ROSs, thus leading to dissociation from DNA. Phosphorylation of the same Cys residue mediated by Stk1-Stp1 might also modulate their target gene regulation. (B) Sequence alignment of SarZ, MgrA, and SarA. The Cys residue (indicated by an arrow) and the surrounding conserved residues are highlighted in red. The alignment was performed with ClustalW2 (61).