Fig. 3.

Femtosecond IR (800 nm) laser pulse treatment (left leg) of a MC7-L1 mouse mammary carcinoma tumor compared to control (right leg) 23 days after laser irradiation. MC7-L1 cells were injected into the right and left thighs of female Balb/c mice. The right side tumor was used as control. Three to four weeks later, mice bearing tumors with a diameter of 3–5 mm were irradiated by femtosecond IR laser pulses. The best laser treatment result here was obtained by irradiating five separate spots (100–300 μm diameter, separated by approximately 1–1.5 mm, with four spots forming a square and one center spot) on the tumors, with 10-min irradiation times for each spot; the laser irradiation and dosimetry conditions were identical to those used for filamentation during chemical dosimetry (see SI Text).