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. 2012 Sep 13;2012:756198. doi: 10.1155/2012/756198

Figure 4.

Figure 4

. Leptin signaling is regulated by PPARγ activation in growth plate chondrocytes. (a) and (b) Real-time RT-PCR analysis of gene expression of leptin ligand (a) and leptin receptor Ob-Rb (b) in growth plate chondrocytes treated with ciglitazone and/or Ad-PPARγ for 5 days. *P < 0.05 versus the expression in control cells. (c) Immunoblotting analysis of the levels of total and phosphorylated STAT3 in the lysates of chondrocytes treated with ciglitazone and/or leptin for 5 days. (d) SOCS3 mRNA expression in growth plate chondrocytes treated with ciglitazone and/or Ad-PPARγ for 5 days. *P < 0.05 versus the expression in control cells.