Table A1.
Astrocyte parameters.
| Astrocyte parameter | Parameter description | Value |
|---|---|---|
| IP*3 | Baseline value of IP3 | 0.16 μ M |
| rIP3 | Rate of IP3 production | 0.5 μ M s−1 |
| τIP3 | IP3 degradation time constant | 7 s |
| τCa | Decay rate of f controlled by level of Cytosolic Ca2+ | 1 s |
| τAG | Decay rate of 2-AG | 10 s |
| τGlu | Decay rate of Glutamate | 100 ms |
| τeSP | Decay rate of eSP | 40 s |
| rC | Maximum rate of CICR | 6 s−1 |
| rL | Ca2+ leakage rate from ER | 0.11 s−1 |
| rGlu | Maximum rate of Glutamate production | 10 μ M s−1 |
| vER | Maximum rate of SERCA uptake | 0.8 μ M s−1 |
| c0 | Total free Ca2+ cytosol concentration | 2 μM |
| kER | SERCA pump activation constant | 0.1 μM |
| c1 | Ratio of ER volume to cytosol volume | 0.185 |
| d1 | IP3 dissociation constant | 0.13 μM |
| d2 | Ca2+ inactivation dissociation constant | 1.049 μM |
| d3 | IP3 dissociation constant | 0.9434 μM |
| d5 | Ca2+ activation dissociation constant | 0.08234 μM |
| a2 | IP3R Ca2+ inactivation binding rate | 0.2 μM s−1 |
| meSP | e-SP weighting factor | 55 × 103 |
| Ca2+ Threshold | Astrocyte Glutamate release threshold | 0.3 μM |