Table 2.
Serum biochemistry as a function of residual Klotho expression
| Serum Biochemistries | WT (KL=1) | Ksp-KL−/− (KL >0.7) | Ksp-KL−/− (KL 0.7–0.3) | Ksp-KL−/− (KL <0.3) |
|---|---|---|---|---|
| FGF23 (pg/mL) | 83.3 (43.3–122.8) | 115.3 (74.3–193.3) | 160.4 (78.9–182.0) | 12,076 (3234–20,917) |
| Phosphate (mmol/L) | 2.71 (1.16–3.02) | 2.63 (1.80–3.20) | 3.09 (2.61–3.46) | 3.69 (3.07–4.32) |
| Calcium (mmol/L) | 1.74 (1.67–1.89) | 1.80 (1.67–1.92) | 1.86 (1.65–1.93) | 1.97 (1.84–2.10) |
| PTH (pg/mL) | 87.2 (65.8–188.9) | 76.5 (54.2–185.1) | 63.0 (53.2–79.4) | 55.2 (53.2–57.1) |
| 1,25(OH)2D (pmol/L) | 176.8 (102.0–168.9) | 134.8 (81.1–215.3) | 161.0 (66.5–382.4) | 130.9 (n=1) |
| Creatinine (μmol/L) | 39.5 (28.5–41.0) | 37.5 (33.5–44.5) | 37.3 (32.5–41.0) | 36.5 (34.5–38.5) |
In wild-type and Ksp-KL−/− mice, categorized into groups based on residual Klotho level, there was a gradual increase in serum FGF23, phosphate, and calcium levels and a reciprocal reduction in PTH level as Klotho expression declined.