Table 3.

Univariate and multivariable Cox proportional hazards regression analysis of covariates versus the primary end point (major cardiovascular events)

Covariates	Univariate Analysis		Multivariable Analysis
	HR (95% CI)	P Value	OR (95% CI)	P Value
Age	1.05 (1.03–1.07)	<0.001	1.06 (1.04–1.08)	<0.001
Female versus male	1.46 (1.09–1.96)	0.01	1.58 (1.07–2.32)	0.02
Duration of diabetes	1.02 (1.002–1.043)	0.03	0.99 (0.97–1.02)	0.88
History of cardiovascular disease	3.02 (1.85–4.91)	<0.001	2.97 (1.79–4.93)	<0.001
Smoker status	1.38 (0.93–2.04)	0.11	1.25 (0.81–1.92)	0.31
Body mass index	0.96 (0.95–1.009)	0.16	0.99 (0.96–1.03)	0.65
Mean BP	0.99 (0.97–1.008)	0.31	0.98 (0.96–1.00)	0.05
HbA1ca	2.87 (1.56–5.27)	0.001	3.17 (1.55–6.48)	0.002
LDL-to-HDL cholesterol ratioa	1.93 (1.26– 2.94)	0.002	2.03 (1.21–3.39)	0.007
Triglycerides	1.001 (0.999–1.003)	0.07	1.00 (0.99–1.002)	0.90
Serum creatininea	2.54 (1.10–5.85)	0.03	0.86 (0.31–2.42)	0.78
UAEa	1.055 (1.026–1.086)	<0.001	1.05 (1.02–1.08)	0.002
Uric acid	1.002 (0.891–1.127)	0.97	1.01 (0.88–1.16)	0.90
Allocation to ACEI	0.818 (0.614–1.089)	0.17	0.84 (0.63–1.13)	0.25
Use of lipid-lowering therapy	0.857 (0.533–1.377)	0.52	0.79 (0.48–1.29)	0.34

OR, odds ratio.

^aVariables log-transformed.