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. 2012 May 30;40(17):e136. doi: 10.1093/nar/gks454

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — WGBS and PBAT. (A) Schematic of the conventional WGBS protocols. Bisulfite treatment follows adaptor tagging, thereby leading to bisulfite-induced fragmentation of adaptor-tagged template DNAs. (B) Schematic of PBAT strategy. Bisulfite treatment precedes adaptor tagging, thereby circumventing bisulfite-induced fragmentation of adaptor-tagged template DNAs. (C) Random priming-mediated PBAT method. Two rounds of random priming on bisulfite-treated DNA generate directionally adaptor-tagged template DNAs.