Table 4.

Known mutations in RNase T2 with clinical relevance. (1)

Mutation type	Affected amino acids	Comment
Missense	Cys184Arg	Disulfide bridge 184–241 missing, destabilizing and sensitizing for oxidation
Deletion	Met 1–Glu 92	Secretion signal peptide deleted; deletion of central part of α+β motif containing β1, β2, α1 and α2
Deletion	Ala 17–Leu 21	Secretion signal peptide deleted
Deletion	Asp 30–Trp 86	Deletion of central part of α+β motif containing β1, β2, α1 and α2
Deletion	Asp 30–Trp 111	Deletion of central part of α+β motif containing β1, β2, α1 and α2
Deletion	Pro 69–Trp 111	Deletion of central part of α+β motif containing β2 and α2
Deletion	Val 165–Gln 189	Deletion of central part of α+β motif containing β4 and α7
Stop	Asp 88–XX–Stop	Rest of protein is not produced
Stop	Asp 88–XXX–Stop	Rest of protein is not produced