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. 2012 Jun 28;40(17):8519–8535. doi: 10.1093/nar/gks630

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Published by Oxford University Press 2012.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — The recruitment of RORα and RORγ to the RORE-containing regulatory regions of Cry1 and Bmal1 was associated with chromatin modifications. (A) The association of H3K9Ac with the RORE-containing regulatory region of Cry1 and Bmal1 was analyzed by ChIP analysis using chromatin samples prepared from liver of WT, RORα^sg/sg, RORγ⁻^/⁻ and RORα^sg/sgRORγ⁻^/⁻ DKO mice (n = 4) and an anti-H3K9Ac antibody. (B) DNA accessibility at the RORE sites was assessed by FAIRE-QPCR analysis. FAIRE-QPCR at the RORE-containing region indicated and at a downstream distal site was performed using chromatin prepared from WT, RORα^sg/sg and RORγ⁻^/⁻ livers collected at ZT10 or ZT22. Data represent mean ±SEM; *P < 0.05, ***P < 0.001 by ANOVA.

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