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. 2012 Jun 28;40(17):8440–8448. doi: 10.1093/nar/gks646

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Influence of caffeine and CHK1 inhibition on checkpoint signalling. (A) Levels of phospho-ATM (S1981), ATM, phospho-CHK1 (S345), CHK1, γH2AX and α-tubulin in Polη-deficient XP30RO and restored cells after 6 h repair in the absence or presence of 1 mM caffeine, following UVC irradiation (10 J/m²) as determined by western blotting. (B) Levels of phospho-ATM (S1981), ATM, phospho-CHK1 (S345), CHK1, γH2AX and α-tubulin in Polη-deficient XP30RO and restored cells, UVC irradiated (10 J/m²) and allowed to repair for 6 h in the absence or presence of 0.5 µM CHK1 inhibitor CEP-3891, as visualized by western blotting.