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Regression of Cu deficient heart hypertrophy by Cu repletion. Mice were fed Cu-deficient diet (CuD) along with Cu-adequate controls (CuA) for 4 w, and then switched to Cu-adequate diet for 2 w. The regression of heart hypertrophy was examined at 1 w (R1w) and 2 w (R2w) after Cu repletion. Hypertrophy was evidenced by increased wall thickness and decreased chamber lumen and regression evidenced by reversal of the changes.
