Table 3.

Sirtuin activators and metabolic effects.

Compound name	Metabolic effects	Ref.
Resveratrol	Improves insulin sensitivity	[99,117,140,141,209]
	Improves hyperglycemia	[140,141]
	Increases mitochondrial biogenesis	[101,137]
	Increases glucose uptake	[210–214]
	Increases lipid transport and β-oxidation in skeletal muscle	[137,141]
	Regulates hepatic gluconeogenesis	[117,140]
	Improves ketoacidosis and muscle protein degradation in T1DM	[136]
	Increases insulin secretion in pancreatic β cells	[77,215]
	Improves hepatic steatosis and hepatocyte ballooning	[208,216,217]
	Improves dyslipidemia	[93,218–220]
	Inhibits adipogenesis	[112,114,221,222]
	Protects against inflammation	[139,141,223,224]
	Protects against oxidative stress	[138,209,223,225]
SRT1720	Improves glucose homeostasis	[104,155]
	Increases insulin sensitivity	[104,155]
	Increases mitochondrial function	[104,155]
	Reduces lipogenic gene expression	[96,155,226]
NMN	Protects against inflammation in pancreatic islets	[227]
	Increases glucose-stimulated insulin secretion	[160,162,207]
	Improves glucose tolerance in obesity	[162]
	Improves glucose and lipid homeostasis in age-induced diabetes	[162,207]

T1DM: Type 1 diabetes mellitus.