Table 4.

Potential targets of β-carbolines based upon bioactivity data in ChEMBL.

target	CHEMBL compound	bioactivity type and reference	our compound	similarity score
C–C chemokine receptor type 3	CHEMBL33838	IC50 = 325 nM [21]	A	0.79
Leishmania donovani	CHEMBL55830	IC50 = 1.42 µM [22]	4	0.80
Acanthocheilonema viteae	CHEMBL44573	Activity = 94% [23]	6{5}	0.86
Gamma-aminobutyric acid receptor subunit gamma-2	CHEMBL358326	IC50 = 250 nM [24]	6{1}	0.84
5-Hydroxytryptamine receptor 6	CHEMBL370935	Ki = 271.3 nM [25]	7{1}	0.69
3-Hydroxyacyl-CoA dehydrogenase type-2	CHEMBL1382101	Potency = 31.6 µM PubChem AID:893	7{7}	0.64
Benzodiazepine receptors	CHEMBL11901	Ki = 510 nM [26]	1{16}	0.72
Angiotensin-converting enzyme	CHEMBL148616	IC50 = 500 nM [27]	9{1,3}	0.71
Antithrombotic potency	CHEMBL1089460	IC50 = 8.56 nM [28]	9{1,4}	0.69
Mitogen-activated protein kinase 1	CHEMBL44295	Potency = 0.794 µM PubChem AID:995	6{4}	0.82
Breast adenocarcinoma cells	CHEMBL1650665	Inhibition = 78% [29]	6{6}	0.79
DNA polymerase iota	CHEMBL1360719	Potency = 1.78 µM PubChem AID:588590	6{7}	0.85