Table 2.
Entry | Solvent | T (°C) | Base | Conv. (%) |
1 | MeOH | 65 | K2CO3 | 65 |
2 | MeOH | 65 | KF | 59 |
3 | MeOH | 65 | K3PO4 | 65 |
4 | toluene | 90 | K2CO3 | 63 |
5 | THF | 65 | K2CO3 | 63 |
6 | dioxane | 90 | K2CO3 | 85 |
7 | dioxane | 90 | – | 45 |
Entry | Solvent | T (°C) | Base | Conv. (%) |
1 | MeOH | 65 | K2CO3 | 65 |
2 | MeOH | 65 | KF | 59 |
3 | MeOH | 65 | K3PO4 | 65 |
4 | toluene | 90 | K2CO3 | 63 |
5 | THF | 65 | K2CO3 | 63 |
6 | dioxane | 90 | K2CO3 | 85 |
7 | dioxane | 90 | – | 45 |