Scheme 2.
Synthesis of the key compound 16. Reaction conditions: a) O3, MeOH, −50 °C (86%); b) AcOH, piperidine, C6H6, reflux (85%); c) LiAlH4, Et2O (82%); d) Ac2O, pyridine, rt (91%); e) B2H6, 2-methyl-2-butene, 0 °C, THF, NaOH, H2O2 (66%).
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