Table 1. Doubling Time of MCF7 and SK-BR-3 cells in presence of different siRNAs on the CBC-1 (% of control).
Average doubling time (% of control) | ||
siRNA | MCF7 | SK-BR-3 |
ESR1 | 265±38* | 142±35 |
ACTB | No fit | 236±54* |
CTSL2 | 141±12* | 66±6** |
FNTB | 144±8* | 94±11 |
PIK3CA | No fit | 182±34* |
CSK | 164±29* | 108±13 |
DMAP1 | 206±47* | 70±6 |
SCUBE2 | 101±6 | 144±18* |
ESR2 | 112±7 | 150±15* |
ERBB2 | 121±20 | No fit |
indicates siRNA causing a significant suppression (longer doubling time than control).
indicates siRNA stimulating growth (significantly shorter doubling time than control). In some cases the data did not fit the exponential growth model, showing almost complete suppression. Only siRNAs that had the most significant effects in this study are shown.