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. 2012 Sep 26;7(9):e45965. doi: 10.1371/journal.pone.0045965

Figure 1. MiR-145 inhibits cancer cell migration and EMT (A) Expression of miR-145 mimics inhibited EGF-induced chemotaxis in MDA-MB-231 cells.

Figure 1

Statistical analysis was performed by one-way ANOVA.*, P<0.01 versus control. Error bars indicating SD. (B) Expression of miR-145 mimics inhibited cell migration in a wound-healing assay. Statistical analysis was also performed by one-way ANOVA. (Points, mean of three independent experiments; bars, SD.) (C) Cell migration and invasion were inhibited upon treatment with miR-145 mimics. Statistical analysis was assessed by the two-tailed Student’s t test. Columns, mean of three independent experiments; bars, SD. (D) Expression of miR-145 mimics enhanced the expression of E-cadherin, and suppressed the expression of α–smooth muscle actin and Fibronectin. A representive data of there separate experiments is shown. (E) Expression of miR-145 was examined in breast tumor tissues from 41 patients.