Table 5. Which withdrawal symptoms are associated with relapse in Low Severity of Dependence Scale score users?
| Withdrawal Symptom | No relapse (n = 16) | Relapse (n = 5) | Time (within subjects) | Relapse vs no relapse (between subjects) | Time×relapse (interaction) | |||||
| BaselineMedian (IQR) | Abstinence Week 1 Median (IQR) | Baseline Median (IQR) | Abstinence Week 1 Median (IQR) | F(1,19) | P | F(1,19) | P | F(1,19) | P | |
| I had mood swings | 0 (1) | 0.5 (2) | 0 (1) | 0 (0.5) | 0.57 | 0.46 | 0.59 | 0.45 | 2.08 | 0.17 |
| I had hot flashes | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 | 1 | 0 | 1 | 1.65 | 0.22 |
| I felt restless | 0 (2) | 0.5 (1) | 1 (3) | 0 (2) | 0.43 | 0.52 | 0.07 | 0.79 | 1.56 | 0.23 |
| I woke up early | 0 (1.75) | 0 (1) | 0 (2) | 0 (0.5) | 0.3 | 0.59 | 0.28 | 0.61 | 1.08 | 0.31 |
| Imagining being stoned | 0.5 (2) | 0 (1) | 0 (1) | 0 (2.5) | 0.28 | 0.6 | 0.21 | 0.65 | 1.04 | 0.32 |
| I was easily irritated | 0 (1) | 1 (2) | 1 (1.5) | 0 (2) | 0.24 | 0.63 | 0.06 | 0.81 | 0.87 | 0.36 |
| I had trouble getting sleep | 0.5 (1) | 1 (2) | 0 (3) | 0 (2) | 0.22 | 0.65 | 0.22 | 0.65 | 0.79 | 0.39 |
| I had some angry outbursts | 0 (1) | 1 (1.7) | 1 (1.5) | 0 (2.5) | 0.2 | 0.66 | 0.15 | 0.7 | 0.73 | 0.41 |
| I felt anxious | 0 (2) | 0 (1) | 0 (1) | 0 (1.5) | 0.15 | 0.7 | 0.01 | 0.94 | 0.54 | 0.47 |
| Thinking about smoking | 1 (2) | 1 (2) | 0 (1.5) | 0 (2.5) | 1.29 | 0.72 | 0.27 | 0.61 | 0.47 | 0.5 |
| I had a stomach ache | 0 (1) | 0 (1) | 0 (0) | 0 (0.5) | 0.12 | 0.73 | 2.64 | 0.12 | 0.45 | 0.51 |
| I woke up sweating at night | 0 (0) | 0 (0) | 0 (0.5) | 0 (1.5) | 0.11 | 0.74 | 0.33 | 0.58 | 0.41 | 0.53 |
| I felt nervous | 0 (0.75) | 0 (1) | 0 (0.5) | 0 (1) | 0.1 | 0.75 | 0.01 | 0.91 | 0.38 | 0.55 |
| Total CWS functional impairment score | 6 (11) | 12.5 (16) | 13 (15) | 8 (18) | 0.1 | 0.75 | 0.2 | 0.66 | 0.37 | 0.55 |
| I had a headache | 0 (2.75) | 1 (1) | 0 (0.5) | 0 (0.5) | 0.1 | 0.76 | 2.08 | 0.17 | 0.35 | 0.56 |
| I yawned a lot | 0 (1.75) | 0 (0) | 0 (1) | 0 (1) | 0.08 | 0.78 | 0.01 | 0.91 | 0.29 | 0.6 |
| I had no appetite | 0 (1) | 0 (0.75) | 0 (2) | 0 (1) | 0.07 | 0.8 | 0 | 0.95 | 0.24 | 0.63 |
| I felt depressed | 0 (1) | 0 (1) | 0 (0.21) | 0 (0.08) | 0.06 | 0.81 | 3.92 | 0.06 | 0.23 | 0.64 |
| Life felt like an uphill struggle | 0 (1.75) | 0 (2) | 0 (0.5) | 0 (0.5) | 0.03 | 0.87 | 0.82 | 0.38 | 0.1 | 0.75 |
| I felt worried | 0 (1) | 0.5 (1) | 0 (1) | 0 (2) | 0.02 | 0.89 | 0.2 | 0.66 | 0.07 | 0.79 |
| I had nightmares or strange dreams | 0 0.75) | 0 (0) | 0 (0.5) | 0 (0.5) | 0.02 | 0.9 | 0.03 | 0.87 | 0.06 | 0.8 |
| I felt tired | 2 (2.75) | 1.5 (3) | 2 (3) | 1 (2) | 0.02 | 0.9 | 1.26 | 0.28 | 0.05 | 0.82 |
| I felt physically tense | 0 (1) | 0 (1) | 0 (1) | 0 (1.5) | 0.01 | 0.94 | 0 | 0.98 | 0.02 | 0.89 |
| I felt nauseous (like vomiting) | 0 (0) | 0 (0.75) | 0 (0) | 0 (0.36) | 0.01 | 0.94 | 0.46 | 0.51 | 0.02 | 0.88 |
Medians and Interquartile range (IQR) with results from a non parametric two way repeated measures ANOVA (using ranked data) comparing change in functional impairment between baseline and abstinence week 1, between people who relapsed to cannabis use during the two weeks of attempted abstinence and those who didn't. rANOVA results are presented for the main effect of relapse group, the main effect of time, and the interaction of time and relapse group. The table is sorted by the F-value from the rANOVA interaction result to reflect the relative order of withdrawal symptoms with respect to their association with relapse (e.g. items at the top of the table are those that are most associated with relapse when comparing functional impairment changes from baseline to week one of abstinence).