Table 2. Percentage expression of cytokines or CD107 marker in CD8 splenocytes from the different vaccine groups in response to immunodominant inserts or vectors.
KDTI | KETI | MVA050 | Exon35 | ||||||||||
cytokine/marker | |||||||||||||
vaccine groups | Peptide | IFN-γ | CD107 | TNF-α | IFN-γ | CD107 | TNF-α | IFN-γ | CD107 | TNF-α | ΦN-γ | CD107 | TNF-α |
MVA-C-MVA-C | E/E | 1.13* | 1.3 | 1.1 | 2.7 | 2.8 | 0.8 | 14.1 | 15.3 | 10.9 | 0.0 | 0.0 | 0.2 |
MVA-K-MVA-K | E/E | 2.3 | 2.9 | 1.8 | 4.0 | 4.8 | 3.1 | 4.7 | 6.3 | 3.4 | 0.0 | 0.1 | 0.3 |
MVA-T-MVA-T | D/D | 1.0 | 1.1 | 1.2 | 0.6 | 0.8 | 1.0 | 9.9 | 11.4 | 8.1 | 0.0 | 0.1 | 0.6 |
Ad35-GE-MVA-T | D/D | 4.3 | 4.7 | 3.9 | 2.0 | 2.6 | 1.9 | 2.6 | 3.4 | 2.5 | 0.3 | 0.3 | 0.6 |
Ad35-GE-Ad35-GE | D/D | 2.1 | 2.1 | 2.1 | 1.2 | 1.1 | 1.2 | 0.5 | 0.8 | 0.7 | 0.1 | 0.2 | 0.4 |
Ad35-GE-MVA-C | D/E | 10.3 | 11.1 | 8.6 | 8.5 | 9.4 | 6.6 | 2.9 | 4.3 | 2.6 | 0.0 | 0.1 | 0.2 |
Ad35-GE-MVA-K | D/E | 8.0 | 8.9 | 7.0 | 6.9 | 7.6 | 6.0 | 3.8 | 5.3 | 3.8 | 0.0 | 0.0 | 0.3 |
naïve | 0.0 | 0.1 | 0.2 | 0.0 | 0.1 | 0.2 | 0.0 | 0.1 | 0.2 | 0.0 | 0.0 | 0.2 |
values represented are means of ICS experiments run in duplicate.