Figure 7.

mRNAs expression of pro-inflammatory and anti-inflammatory cytokinesin vivo. CCl₄ administration induced significant up-regulation of mRNA coding for TNF-alpha, TGF-beta 1, IL-5 and IL-10. Following cell transplantation, at both 5 and 8 days from the injury the pro-inflammatory cytokines mRNA up-regulation was significantly lower compared to mice that received only CCl₄. IL-10 mRNA up-regulation at 5 days was significantly higher compared to CCl₄ group and returned to basal level after 8 days from the damage. Values represent median, negative and positive error bars represent Q1 and Q3, respectively. * Mann Whitney U test vs. PBS group; # Mann Whitney U test vs. CCl₄ group *p < 0.05; ** or ## p < 0.01; *** or ### p < 0.001