Table 1. Inhibition of enzyme activities of respiratory complexes.
% inhibition | ||
LY294002 | Akt inhibitor IV | |
RCI | 14.9±0.87# | 66.5±6.99# |
RCII | 33.7±9.18** | 38.6±7.89** |
RCIII | 26.8±8.25** | 38.1±1.01# |
RCIV | 21.3±4.41** | 42.9±6.06# |
Activities of respiratory complexes I to IV were inhibited by LY294002 (inhibitor of PI3K and mTOR) and Akt inhibitor IV. Values are expressed as % inhibition compared to untreated controls.
p<0.01 and
p<0.005 for n = 3.